Can I use GiO's and another audio interface input/output together in the same session?

Currently, it's possible to aggregate GiO with another USB audio device (using the macOS utility Audio MIDI Setup), but the system may be less tolerant to sleep/wake cycles of the computer, session sample rate changes, and hot-plugging.

It's best to minimize these activities when aggregating.

Keep in mind that with Logic and GarageBand it's possible to assign the input to one device and the output to another without the need to aggregate the devices. In Logic, for example, choose Logic Pro  Preferences Audio, and set Output Device to ONE (for example) and Input Device to GiO.