Are Apogee products compatible with Pro Tools 12?

Yes!  The following products have been tested and are fully compatible with Pro Tools 12 (every version of 12): 

• JAM
• JAM 96k
• MiC
• MiC 96k
• Groove
• GiO
• ONE for Mac (old and new versions)
• ONE for iPad & Mac
• Duet FireWire
• Duet 2
• Duet for iPad & Mac
• Quartet for iPad & Mac
• Ensemble FireWire
• Ensemble Thunderbolt
• Symphony I/O (USB, Symphony, and Pro Tools HD modes)
• Symphony I/O MkII (Thunderbolt and Pro Tools HD)
• Symphony 64 PCIe
• Symphony 64 | ThunderBridge
• X-Symphony equipped X-Series and Rosetta Series Converters
• X-HD equipped X-Series and Rosetta Series Converters